EP.WE.852Role of Prophylactic steroids in the prevention of post-thyroidectomy hypocalcaemia and voice dysfunction

Abstract Aim Total thyroidectomy, being a common surgical option, for multinodular goitre and selective cases of Graves’ disease, is associated with risks related to temporary hypocalcaemia vocal quality dysfunction. Dexamethasone, as steroid, has well-established anti-inflammatory immune-modulating effects. As researchers continue understand its pathophysiology on voice quality, we aim assess the effect preoperative dexamethasone used improve cord function/post-thyroidectomy disorder. Methods We conducted single-centre, non-randomised, double-blinded placebo-controlled, parallel-group study short follow-up in public sector hospital from January 2014 December 2019. Patients were equally distributed two groups compare placebo disorder Results Out 192 patients, 36 (18.75) male patients while 156 (81.25) female. Age range was 18 60. Eighteen had both low calcium level at 24 hours after operation hypocalcemic symptoms, which 4 remain have third postoperative day. Forty defined having dysfunction scored using Voice scale. Of these 40 dysfunction, 8 blood only 2 remained 6/8 symptomatic first Conclusions Single-dose dexamethasone, during period, safe effective improving transient Temporary dysfunction/post-thyroidectomy